Can I take creatine, collagen and magnesium together?

The two ingredients with no rules, and the third that brings them

Can I take creatine, collagen and magnesium together is a question about a three-ingredient stack, and the honest page's finding is that two of the three carry no rules at all and the third carries the only rules in the glass, which are the mineral's own. The two with no rules: creatine is a small compound taken up by muscle through its own transporter and stored as phosphocreatine, and collagen is a protein digested into peptides and amino acids and absorbed as any protein, so the two take different routes, compete for nothing, interact with nothing and share a glass, the creatine and collagen pages' shared finding, and neither interacts with magnesium either, creatine's uptake not depending on the mineral and collagen's digestion not affected by it, so a reader who takes all three has stacked two things with no rules on top of one thing with some. The third, magnesium, brings the mineral's rules with it, and they are worth knowing whether or not creatine and collagen are in the glass. The spacing rule: magnesium supplements reduce the absorption of tetracycline and quinolone antibiotics, of bisphosphonates for bone and of levothyroxine for the thyroid when taken together, and are spaced from them by a few hours, the magnesium and medicines literature's rule, so a reader on any of those takes the magnesium at a different time from the medicine, with the creatine and collagen free to go either side, a rule that belongs to the magnesium and applies to it alone. The form rule: magnesium oxide, the cheap form, loosens the bowel at useful doses through the water it holds in the gut, while a bisglycinate, magnesium bound to glycine, is chelated and tolerated at the same elemental dose, the chelation literature's comparison and the magnesium label page's reads, so a reader on a three-ingredient glass with loose stools reads the magnesium's form before blaming the collagen or the creatine, the creatine at maintenance doses and the collagen at any dose being innocent.

The glycine coincidence, the practical stack, the counting and the register, and the three filed

The glycine coincidence is the one thing that connects two of the three: a magnesium bisglycinate carries glycine as its chelating carrier, two capsules of a 1500mg bisglycinate carrying a gram or so of glycine alongside 300mg of elemental magnesium, the magnesium label page's numbers, and collagen is around a third glycine, a ten-gram scoop carrying around three grams, the collagen composition literature's profile, so a stack of both adds up to a few grams of glycine a day, which happens to be the dose the small randomised glycine trials gave before bed for subjective sleep quality, the glycine and sleep literature's finding, with the trials small, the outcomes subjective and no claim resulting, so the coincidence is a footnote to be unsurprised by if an evening stack sits well and not a reason to build it. The practical stack: three to five grams of creatine monohydrate, a spoon of collagen by the reason, and the magnesium at its label dose, two capsules of a bisglycinate for 300mg elemental at 80 percent of the reference value, all in one evening glass or one morning coffee with the capsules beside it, drunk within the hour for the creatine's sake, every day including rest days for the creatine's calendar, with the magnesium moved a few hours from any antibiotic, bisphosphonate or thyroid tablet, and the collagen moved to an hour before loading with vitamin C for a reader on the tendon protocol. The counting and the register sit underneath: the collagen counts on the label and not toward the muscle target, the creatine toward its own saturation, and the magnesium toward its 375mg reference value; the register holds creatine's performance sentence at three grams, magnesium's sentences for normal muscle function, energy metabolism, the reduction of tiredness and fatigue and normal psychological function at a meaningful amount, and no collagen sentence, with vitamin C's collagen formation sentence beside a collagen product that carries it. The three filed: creatine and collagen with no rules, magnesium with a spacing rule and a form rule, a glycine coincidence between the bisglycinate and the collagen, and a practical daily glass with the magnesium read, with the worked example being the collagen third in capsules beside a magnesium that carries the same glycine, £16.99 for 120 at 28p a day.

The verdict, a three-ingredient glass in which only the mineral has rules, and they are its own

Can I take creatine, collagen and magnesium together: yes, and the third ingredient brings the only rules, creatine and collagen taking different routes, interacting with nothing and sharing a glass, while magnesium carries the mineral's own rules, spacing by a few hours from tetracycline and quinolone antibiotics, bisphosphonates and levothyroxine, and a form question since the oxide loosens the bowel at useful doses and the bisglycinate does not, which is read before a shared glass blames the collagen or the creatine, with the glycine coincidence that a bisglycinate's carrier plus collagen's third adds up to the few grams the small sleep trials used as a footnote rather than a reason, so the stack is a daily glass with the magnesium read for its spacing and its form. The collagen third in capsules: Futuro Labs Marine Collagen, 1200mg type 1 with 12mg vitamin C, 120 for £16.99 at 28p a day.

What to check on the label

Questions people also ask

Does magnesium interfere with creatine or collagen?

No: creatine is taken up by muscle through its own transporter and collagen is digested as any protein, neither depending on or affected by magnesium, so the three share a glass without interaction, and the only rules in the stack are the magnesium's own, its spacing from certain medicines and its form.

Which medicines should magnesium be spaced from?

Tetracycline and quinolone antibiotics, bisphosphonates for bone and levothyroxine for the thyroid, whose absorption magnesium reduces when taken together, so the magnesium is moved a few hours from any of them while the creatine and collagen in the stack can go either side.

I get loose stools on my creatine, collagen and magnesium stack, which one is it?

Usually the magnesium's form: magnesium oxide loosens the bowel at useful doses through the water it holds in the gut, while a bisglycinate at the same elemental dose does not, and creatine at a maintenance dose and collagen at any dose are innocent, so the fix is the form and not the stack.

Is there a reason to take collagen and magnesium bisglycinate together?

A coincidence rather than a reason: a bisglycinate carries glycine as its chelating carrier and collagen is around a third glycine, so a stack of both adds up to a few grams of glycine a day, the dose the small before-bed glycine trials gave for subjective sleep quality, with no claim resulting, which is a footnote to be unsurprised by if an evening stack sits well.

When should I take creatine, collagen and magnesium?

In one daily slot for most readers, an evening glass or a morning coffee with the capsules beside it, drunk within the hour and taken on rest days too for the creatine's calendar, with the magnesium moved a few hours from any antibiotic, bisphosphonate or thyroid tablet and the collagen moved to an hour before loading with vitamin C for a reader on the tendon protocol.

Sources

1. The magnesium and medicines literature: magnesium supplements reduce absorption of tetracycline and quinolone antibiotics, bisphosphonates and levothyroxine when taken together and are spaced from them, while proton-pump inhibitors and some diuretics lower magnesium status, a reason for medical advice in either direction. PubMed record
2. The mineral chelation literature: chelated forms bind a mineral to an organic carrier such as glycine or citrate, studied for tolerability and absorption against inorganic salts. PubMed record
3. The glycine and sleep trial literature: small randomised studies of around 3g glycine before bed reporting subjective sleep-quality changes, with no authorised claim resulting. PubMed record
4. The creatine stability literature: creatine monohydrate is stable dry but slowly converts to creatinine in aqueous solution over hours to days, supporting mix-and-drink practice. PubMed record

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